Companies are claiming all around the world that nobody is able to differentiate between their new GMOs and plants that have acquired the same targeted mutation naturally or through traditional breeding methods. But a contrario they claim to be able to accurately characterize their own plant varieties by genetic tools, as evidenced by the work performed at the International Union for the Protection of New Varieties of Plants (UPOV). Fortunately, the same methods and tools are usable to differentiate new GMOs from non-GM plants, provided a political will exists to roll out the appropriate protocols.